Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial
Joint Authors
Tongtawee, Taweesak
Kaewpitoon, Soraya
Dechsukhum, Chavaboon
Matrakool, Likit
Kaewpitoon, Natthawut
Loyd, Ryan A.
Panpimanmas, Sukij
Leeanansaksiri, Wilairat
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
To evaluate the effect of Lactobacillus delbrueckii subsp.
bulgaricus and Streptococcus thermophilus to Helicobacter pylori eradication in different periods of therapeutic protocol.
Methods.
Infected patients were randomized to one-week tailored triple therapy (esomeprazole 20 mg bid, clarithromycin 500 mg bid/metronidazole 400 mg tid if clarithromycin resistant, and amoxicillin 1000 mg bid) with placebo (group 1, n=100); one week of pretreatment with probiotics (group 2, n=100); and one week of pretreatment with probiotic followed by one week of the same probiotics after treatment (group 3, n=100).
Result.
PP analysis involved 292 patients, 98 in group 1, 97 in group 2, and 97 in group 3.
Successful eradication was observed in 229 patients; by PP analysis, the eradication rates were significantly higher (P<0.01, 95% CI; 0.71–0.97) in group 2 and group 3 than group 1.
ITT analysis eradication rates were significantly higher in group 2 and group 3 than group 1 (P<0.01 95% CI; 0.72–0.87), and there is no significant difference between the three groups (P=0.32) in terms of adverse events.
Conclusion.
Adding probiotics before or before and after tailored treatment can improve Helicobacter pylori eradication rates.
This trial is registered with Thai Clinical Trials Registry number: TCTR20141209001.
American Psychological Association (APA)
Tongtawee, Taweesak& Dechsukhum, Chavaboon& Leeanansaksiri, Wilairat& Kaewpitoon, Soraya& Kaewpitoon, Natthawut& Loyd, Ryan A.…[et al.]. 2015. Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064013
Modern Language Association (MLA)
Tongtawee, Taweesak…[et al.]. Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial. Gastroenterology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1064013
American Medical Association (AMA)
Tongtawee, Taweesak& Dechsukhum, Chavaboon& Leeanansaksiri, Wilairat& Kaewpitoon, Soraya& Kaewpitoon, Natthawut& Loyd, Ryan A.…[et al.]. Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064013