Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future
Joint Authors
Gitto, S.
Vitale, G.
Villa, E.
Andreone, P.
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Nonalcoholic steatohepatitis has become one of the most common liver-related health problems.
This condition has been linked to an unhealthy diet and weight gain, but it can also be observed in nonobese people.
The standard of care is represented by the lifestyle intervention.
However, because this approach has several limitations, such as a lack of compliance, the use of many drugs has been proposed.
The first-line pharmacological choices are vitamin E and pioglitazone, both showing a positive effect on transaminases, fat accumulation, and inflammation.
Nevertheless, vitamin E has no proven effect on fibrosis and on long-term morbidity and mortality and pioglitazone has a negative impact on weight.
Other drugs have been studied such as metformin, ursodeoxycholic acid, statins, pentoxiphylline, and orlistat with only partially positive results.
Among the emerging treatments, telmisartan is particularly interesting as it seems to have an impact on insulin resistance, liver steatosis, inflammation, and fibrosis.
However, the pathogenesis of steatohepatitis is highly complex and is determined by different parallel hits; indeed, the association of different drugs that act on various levels has been suggested.
In conclusion, lifestyle intervention should be optimised and the associations of different drugs should be tested in large studies with long-term outcomes.
American Psychological Association (APA)
Gitto, S.& Vitale, G.& Villa, E.& Andreone, P.. 2015. Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1064106
Modern Language Association (MLA)
Gitto, S.…[et al.]. Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future. Gastroenterology Research and Practice No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1064106
American Medical Association (AMA)
Gitto, S.& Vitale, G.& Villa, E.& Andreone, P.. Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1064106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064106