An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease
Joint Authors
Sarıtaş Yüksel, Elif
Ünsal, Belkıs
Paköz, Zehra Betül
Vatansever, Sezgin
Arabul, Mahmut
İpek, Serkan
Cekic, Cem
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Aim.
While there are many well-defined serological markers for inflammatory bowel disease (IBD), there is limited evidence that they positively affect clinical outcomes.
This study aimed to evaluate the correlation between hepcidin serum levels and disease activity in IBD.
Materials and Methods.
Eighty-five consecutive IBD patients were enrolled in the study.
Hepcidin serum levels were assessed using an enzyme-linked immunosorbent assay (ELISA) and were compared with disease activity as well as the interleukin-6 (IL-6) and C-reactive protein (CRP) levels.
Results.
The mean hepcidin serum levels in Crohn’s disease (CD) patients in remission and in the active phase were 3837 ± 1436 and 3752 ± 1274 pg/mL, respectively P = 0.613 .
The mean hepcidin serum levels in ulcerative colitis (UC) patients in remission and in the active phase were 4285 ± 8623 and 3727 ± 1176 pg/mL, respectively P = 0.241 .
Correlation analysis between inflammatory markers and hepcidin serum levels indicated that there was no correlation between hepcidin levels and IL-6 P = 0.582 or CRP P = 0.783 .
Conclusion.
As an acute-phase protein, hepcidin seems to have a lower efficacy than other parameters in the detection of activation in IBD.
American Psychological Association (APA)
Paköz, Zehra Betül& Cekic, Cem& Arabul, Mahmut& Sarıtaş Yüksel, Elif& İpek, Serkan& Vatansever, Sezgin…[et al.]. 2015. An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1064125
Modern Language Association (MLA)
Paköz, Zehra Betül…[et al.]. An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease. Gastroenterology Research and Practice No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1064125
American Medical Association (AMA)
Paköz, Zehra Betül& Cekic, Cem& Arabul, Mahmut& Sarıtaş Yüksel, Elif& İpek, Serkan& Vatansever, Sezgin…[et al.]. An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1064125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064125