Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial
Joint Authors
Eisig, Jaime Natan
Navarro-Rodriguez, Tomás
Teixeira, Ana Cristina Sá
Silva, Fernando Marcuz
Mattar, Rejane
Chinzon, Decio
Haro, Christiane
Diniz, Márcio Augusto
Moraes-Filho, Joaquim Prado
Fass, Ronnie
Barbuti, Ricardo Correa
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To compare 10-day standard triple therapy versus sequential therapy as first-line treatment in patients infected with H.
pylori.
Methods.
One hundred H.
pylori positive patients (diagnosed by rapid urease test and histology), with average age of 47.2, M/F = 28/72, were randomized to receive either standard triple treatment (TT) as follows: lansoprazole 30 mg, clarithromycin 500 mg, and amoxicillin 1 g, b.i.d.
for ten days, or sequential treatment (ST) as follows: lansoprazole 30 mg, amoxicillin and placebo 1.0 g b.i.d for the first five days, followed by lansoprazole 30 mg, clarithromycin 500 mg, and tinidazole 500 mg b.i.d, for the remaining five days.
Eradication rates were determined 60 days after treatment by urease, histology, or 13C-urea breath test.
Results.
In intention to treat (ITT) analysis, the rate of H.
pylori eradication in the TT and ST groups was the same for both regimens as follows: 86% (43/50), 95% CI 93,3 to 73.4%.
In Per protocol (PP) analysis, the rate of H.
pylori eradication in the TT and ST groups was 87.8% (43/49), 95% CI 94,5 to 75.3% and 89.6% (43/48), 95% CI 95,8 to 77.3%, respectively.
Conclusions.
In Brazil, standard triple therapy is as equally effective as sequential therapy in eradicating Helicobacter pylori patients.
This study was registered under Clinical Trials with number ISRCTN62400496.
American Psychological Association (APA)
Eisig, Jaime Natan& Navarro-Rodriguez, Tomás& Teixeira, Ana Cristina Sá& Silva, Fernando Marcuz& Mattar, Rejane& Chinzon, Decio…[et al.]. 2015. Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064127
Modern Language Association (MLA)
Eisig, Jaime Natan…[et al.]. Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial. Gastroenterology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1064127
American Medical Association (AMA)
Eisig, Jaime Natan& Navarro-Rodriguez, Tomás& Teixeira, Ana Cristina Sá& Silva, Fernando Marcuz& Mattar, Rejane& Chinzon, Decio…[et al.]. Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1064127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064127