![](/images/graphics-bg.png)
Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance
Joint Authors
Gundersen, Doris
Hausken, Trygve
Mazzawi, Tarek
El-Salhy, Magdy
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The large intestine contains five types of endocrine cells that regulate its functions by sensing its luminal contents and releasing specific hormones.
Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients.
Most IBS patients relate their symptoms to certain food elements.
The present study investigated the effect of dietary guidance on the total endocrine cells of the large intestine as detected by CgA in 13 IBS patients.
Thirteen control subjects were also included.
Each patient received three sessions of dietary guidance.
Colonoscopies were performed on controls and patients (at baseline and at 3–9 months after receiving guidance).
Biopsy samples from the colon and rectum were immunostained for CgA and quantified by computerized image analysis.
The densities of CgA cells in the total colon (mean ± SEM) among the controls and the IBS patients before and after receiving dietary guidance were 83.3 ± 10.1 , 38.6 ± 3.7 , and 64.7 ± 4.2 cells/mm2, respectively ( P = 0.0004 ), and were unchanged in the rectum.
In conclusion, the increase in CgA cell density after receiving dietary guidance may reflect a change in the densities of the large intestinal endocrine cells causing an improvement in the IBS symptoms.
American Psychological Association (APA)
Mazzawi, Tarek& Gundersen, Doris& Hausken, Trygve& El-Salhy, Magdy. 2015. Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064129
Modern Language Association (MLA)
Mazzawi, Tarek…[et al.]. Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064129
American Medical Association (AMA)
Mazzawi, Tarek& Gundersen, Doris& Hausken, Trygve& El-Salhy, Magdy. Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064129