A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients
Joint Authors
Iijima, Hiroko
Sakai, Yoshiyuki
Yoh, Kazunori
Nishiguchi, Shuhei
Takashima, Tomoyuki
Hashimoto, Kenji
Takata, Ryo
Hasegawa, Kunihiro
Aoki, Tomoko
Enomoto, Hirayuki
Ishii, Akio
Iwata, Yoshinori
Saito, Masaki
Tanaka, Hironori
Nakamura, Hideji
Aizawa, Nobuhiro
Imanishi, Hiroyasu
Ikeda, Naoto
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported.
The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) positive patients.
Methods.
A total of 394 HCV-positive patients were assessed based on the values of a new index (GA/HbA1c/BTR).
The index findings were used to investigate the relationship with the degree of liver fibrosis.
Results.
The new index showed an association with the stage of fibrosis (METAVIR scores: F0-1: 0.42 ± 0.10, F2: 0.48 ± 0.15, F3: 0.56 ± 0.22, and F4: 0.71 ± 0.30).
The index was negatively correlated with three variables of liver function: the prothrombin time percentage ( P < 0.0001 ), albumin level ( P < 0.0001 ), and cholinesterase level ( P < 0.0001 ).
The new index showed a higher correlation related to liver function than FIB-4 and the APRI did.
In addition, the index showed a higher AUROC value than that of FIB-4 and the APRI for prediction of liver cirrhosis.
Conclusion.
The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients.
American Psychological Association (APA)
Enomoto, Hirayuki& Aizawa, Nobuhiro& Nakamura, Hideji& Takata, Ryo& Sakai, Yoshiyuki& Iwata, Yoshinori…[et al.]. 2015. A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064338
Modern Language Association (MLA)
Enomoto, Hirayuki…[et al.]. A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064338
American Medical Association (AMA)
Enomoto, Hirayuki& Aizawa, Nobuhiro& Nakamura, Hideji& Takata, Ryo& Sakai, Yoshiyuki& Iwata, Yoshinori…[et al.]. A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064338