Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases
Joint Authors
Meteoglu, Ibrahim
Erdogdu, Ibrahim Halil
Tuncyurek, Pars
Coskun, Adil
Culhaci, Nil
Erkus, Muhan
Barutca, Sabri
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Colorectal cancer (CRC) is the third most frequent malignancy.
Many factors such as NF-κB, matrix metalloproteinase-1 (MMP-1), p53, and Ki-67 are likely to be involved in its development and progression.
Lymph node metastases indicate increased tumor burden and tumor cell heterogeneity and affect both the treatment strategies and the prognosis.
In this study, expressions of NF-κB, MMP-1, p53, and Ki-67 were between the primary tumors and lymph node metastases in 110 Dukes’ stage C, CRC cases by immunohistochemical methods, related to patients’ clinical outcomes.
NF-κB, p53, and Ki-67 expressions were significantly higher in the metastatic lymph nodes compared to the primary tumor tissues ( P = 0.04 , P = 0.04 , and P = 0.01 , resp.).
In the metastatic lymph nodes NF-κB expression was correlated with both p53 ( r = 0.546 , P = 0.003 ) and Ki-67 ( r = 0.586 , P = 0.0001 ) expressions.
The univariant and multivariant analyses showed that only “pT stage” preserved an independent prognostic significance for recurrence-free survival rates and 5-year overall survival rates ( P < 0.001 for both).
Metastatic cells can acquire different biological characteristics compared to their primaries.
Elucidation of properties acquired by metastatic cells is important in order to better determine prognosis, reverse drug resistance, and discover new treatment alternatives.
American Psychological Association (APA)
Meteoglu, Ibrahim& Erdogdu, Ibrahim Halil& Tuncyurek, Pars& Coskun, Adil& Culhaci, Nil& Erkus, Muhan…[et al.]. 2015. Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064357
Modern Language Association (MLA)
Meteoglu, Ibrahim…[et al.]. Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases. Gastroenterology Research and Practice No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064357
American Medical Association (AMA)
Meteoglu, Ibrahim& Erdogdu, Ibrahim Halil& Tuncyurek, Pars& Coskun, Adil& Culhaci, Nil& Erkus, Muhan…[et al.]. Nuclear Factor Kappa B, Matrix Metalloproteinase-1, p53, and Ki-67 Expressions in the Primary Tumors and the Lymph Node Metastases of Colorectal Cancer Cases. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064357