Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection
Joint Authors
Park, Kwang-Kuk
Seo, Kyung Won
Yoon, Ki Young
Lee, Sang Ho
Jang, Hee Kyung
Shin, Yeon Myeong
Yang, Song-I
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The purpose of this study was to evaluate the relationships between HER2 overexpression in the tumor and MUC2, MUC5AC, MUC6, and p53 status and clinicopathological characteristics of gastric cancer patients.
Methods.
This retrospective study included 282 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between April 2011 and December 2012.
All tumor samples were examined for HER2 expression by immunohistochemistry (IHC) and MUC2, MUC5AC, MUC6, and p53 expression by staining.
A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors.
Results.
The HER2-positive rate was 18.1%.
Although no association was found between HER2 expression and MUC5AC, the expression of MUC2, MUC6, and p53 was significantly correlated with HER2 positivity, respectively (P = 0.004, 0.037, 0.002).
Multivariate analysis revealed that HER2 overexpression and nodal status were independent prognostic factors.
Conclusions.
HER2 overexpression in gastric carcinoma is an independent poor prognostic factor.
American Psychological Association (APA)
Park, Kwang-Kuk& Yang, Song-I& Seo, Kyung Won& Yoon, Ki Young& Lee, Sang Ho& Jang, Hee Kyung…[et al.]. 2015. Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064358
Modern Language Association (MLA)
Park, Kwang-Kuk…[et al.]. Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064358
American Medical Association (AMA)
Park, Kwang-Kuk& Yang, Song-I& Seo, Kyung Won& Yoon, Ki Young& Lee, Sang Ho& Jang, Hee Kyung…[et al.]. Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064358
