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Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya
Joint Authors
Pintye, Jillian
Langat, Agnes
Singa, Benson
Kinuthia, John
Odeny, Beryne
Katana, Abraham
Nganga, Lucy
McGrath, Christine J.
John-Stewart, Grace C.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and preexposure prophylaxis regimens.
We evaluated the relationship of prenatal TDF use and growth outcomes among Kenyan HIV-exposed uninfected (HEU) infants.
Materials and Methods.
We included PCR-confirmed HEU infants enrolled in a cross-sectional survey of mother-infant pairs conducted between July and December 2013 in Kenya.
Maternal ART regimen during pregnancy was determined by self-report and clinic records.
Six-week and 9-month z-scores for weight-for-age (WAZ), weight-for-length (WLZ), length-for-age (LAZ), and head circumference-for-age (HCAZ) were compared among HEU infants with and without TDF exposure using t-tests and multivariate linear regression models.
Results.
Among 277 mothers who received ART during pregnancy, 63% initiated ART before pregnancy, of which 89 (32%) used TDF.
No differences in birth weight (3.0 kg versus 3.1 kg, p=0.21) or gestational age (38 weeks versus 38 weeks, p=0.16) were detected between TDF-exposed and TDF-unexposed infants.
At 6 weeks, unadjusted mean WAZ was lower among TDF-exposed infants (−0.8 versus −0.4, p=0.03), with a trend towards association in adjusted analyses (p=0.06).
There were no associations between prenatal TDF use and WLZ, LAZ, and HCAZ in 6-week or 9-month infant cohorts.
Conclusion.
Maternal TDF use did not adversely affect infant growth compared to other regimens.
American Psychological Association (APA)
Pintye, Jillian& Langat, Agnes& Singa, Benson& Kinuthia, John& Odeny, Beryne& Katana, Abraham…[et al.]. 2015. Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya. Infectious Diseases in Obstetrics and Gynecology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064375
Modern Language Association (MLA)
Pintye, Jillian…[et al.]. Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya. Infectious Diseases in Obstetrics and Gynecology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064375
American Medical Association (AMA)
Pintye, Jillian& Langat, Agnes& Singa, Benson& Kinuthia, John& Odeny, Beryne& Katana, Abraham…[et al.]. Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya. Infectious Diseases in Obstetrics and Gynecology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064375