Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods
Joint Authors
Sher, Nawab
Fatima, Nasreen
Perveen, Shahnaz
Wafa Sial, Alisha
Siddiqui, Farhan Ahmed
Source
International Journal of Analytical Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This paper demonstrates colorimetric visible spectrophotometric quantification methods for amino acid, namely, tranexamic acid and pregabalin.
Both drugs contain the amino group, and when they are reacted with 2,4-dinitrophenol and 2,4,6-trinitrophenol, they give rise to yellow colored complexes showing absorption maximum at 418 nm and 425 nm, respectively, based on the Lewis acid base reaction.
Detailed optimization process and stoichiometric studies were conducted along with investigation of thermodynamic features, that is, association constant and standard free energy changes.
The method was linear over the concentration range of 0.02–200 µgmL−1 with correlation coefficient of more than 0.9990 in all of the cases.
Limit of detection was in range from 0.0041 to 0.0094 µgmL−1 and limit of quantification was in the range from 0.0137 to 0.0302 µgmL−1.
Excellent recovery in Placebo spiked samples indicated that there is no interference from common excipients.
The analytical methods under proposal were successfully applied to determine tranexamic acid and pregabalin in commercial products.
t -test and F ratio were evaluated without noticeable difference between the proposed and reference methods.
American Psychological Association (APA)
Sher, Nawab& Fatima, Nasreen& Perveen, Shahnaz& Siddiqui, Farhan Ahmed& Wafa Sial, Alisha. 2015. Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064412
Modern Language Association (MLA)
Sher, Nawab…[et al.]. Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1064412
American Medical Association (AMA)
Sher, Nawab& Fatima, Nasreen& Perveen, Shahnaz& Siddiqui, Farhan Ahmed& Wafa Sial, Alisha. Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064412