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A New Technique for Quantitative Determination of Dexamethasone in Pharmaceutical and Biological Samples Using Kinetic Spectrophotometric Method
Joint Authors
Akhoundi-Khalafi, Ali Mohammad
Shishehbore, Masoud Reza
Source
International Journal of Analytical Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dexamethasone is a type of steroidal medications that is prescribed in many cases.
In this study, a new reaction system using kinetic spectrophotometric method for quantitative determination of dexamethasone is proposed.
The method is based on the catalytic effect of dexamethasone on the oxidation of Orange G by bromate in acidic media.
The change in absorbance as a criterion of the oxidation reaction progress was followed spectrophotometrically.
To obtain the maximum sensitivity, the effective reaction variables were optimized.
Under optimized experimental conditions, calibration graph was linear over the range 0.2–54.0 mg L−1.
The calculated detection limit (3sb/m) was 0.14 mg L−1 for six replicate determinations of blank signal.
The interfering effect of various species was also investigated.
The present method was successfully applied for the determination of dexamethasone in pharmaceutical and biological samples satisfactorily.
American Psychological Association (APA)
Akhoundi-Khalafi, Ali Mohammad& Shishehbore, Masoud Reza. 2015. A New Technique for Quantitative Determination of Dexamethasone in Pharmaceutical and Biological Samples Using Kinetic Spectrophotometric Method. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064426
Modern Language Association (MLA)
Akhoundi-Khalafi, Ali Mohammad& Shishehbore, Masoud Reza. A New Technique for Quantitative Determination of Dexamethasone in Pharmaceutical and Biological Samples Using Kinetic Spectrophotometric Method. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064426
American Medical Association (AMA)
Akhoundi-Khalafi, Ali Mohammad& Shishehbore, Masoud Reza. A New Technique for Quantitative Determination of Dexamethasone in Pharmaceutical and Biological Samples Using Kinetic Spectrophotometric Method. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064426