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Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting
Joint Authors
Imbriani, Marcello
Oddone, Enrico
Negri, Sara
Bellinzona, Massimo
Martino, Silvia
Di Tuccio, Marcello
Grignani, Elena
Cottica, Danilo
Source
International Journal of Analytical Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Occupational exposures to glucocorticoids are still a neglected issue in some work environments, including pharmaceutical plants.
We developed an analytical method to quantify simultaneously 21 glucocorticoids using UPLC coupled with mass spectrometry to provide a basis to carry out environmental monitoring.
Samples were taken from air, hand-washing tests, pad-tests and wipe-tests.
This paper reports the contents of the analytical methodology, along with the results of this extensive environmental and personal monitoring of glucocorticoids.
The method in UPLC-MS turned out to be suitable and effective for the aim of the study.
Wipe-test and pad-test desorption was carried out using 50 mL syringes, a simple technique that saves time without adversely affecting analyte recovery.
Results showed a widespread environmental pollution due to glucocorticoids.
This is of particular concern.
Evaluation of the dose absorbed by each worker and identification of a biomarker for occupational exposure will contribute to assessment and prevention of occupational exposure.
American Psychological Association (APA)
Oddone, Enrico& Negri, Sara& Bellinzona, Massimo& Martino, Silvia& Di Tuccio, Marcello& Grignani, Elena…[et al.]. 2015. Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064433
Modern Language Association (MLA)
Oddone, Enrico…[et al.]. Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064433
American Medical Association (AMA)
Oddone, Enrico& Negri, Sara& Bellinzona, Massimo& Martino, Silvia& Di Tuccio, Marcello& Grignani, Elena…[et al.]. Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064433