Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy
Joint Authors
Shi, Xinyuan
Xu, Bing
Qiao, Yanjiang
Luo, Gan
Li, Jianyu
Dai, Shengyun
Source
International Journal of Analytical Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations.
The active pharmaceutical ingredients have a direct impact on the herbal extract’s efficacy, while the physical properties of raw material affect the pharmaceutical manufacturing process and the final products’ quality.
In this study, tanshinone extract powders from Salvia miltiorrhiza which are widely used for the treatment of cardiovascular diseases in the clinic are taken as the research object.
Both the chemical information and physical information of tanshinone extract powders are analyzed by near infrared (NIR) spectroscopy.
The partial least squares (PLS) and least square support vector machine (LS-SVM) models are investigated to build the relationship between NIR spectra and reference values.
PLS models performed well for the content of crytotanshinone, tanshinone IIA, the moisture, and average median particle size, while, for specific surface area and tapped density, the LS-SVM models performed better than the PLS models.
Results demonstrated NIR to be a valid and fast process analytical technology tool to simultaneously determine multiple quality attributes of herbal extract powders and indicated that there existed some nonlinear relationship between NIR spectra and physical quality attributes.
American Psychological Association (APA)
Luo, Gan& Xu, Bing& Shi, Xinyuan& Li, Jianyu& Dai, Shengyun& Qiao, Yanjiang. 2015. Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064436
Modern Language Association (MLA)
Luo, Gan…[et al.]. Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064436
American Medical Association (AMA)
Luo, Gan& Xu, Bing& Shi, Xinyuan& Li, Jianyu& Dai, Shengyun& Qiao, Yanjiang. Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064436