Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology
Joint Authors
Bulduk, Ibrahim
Gezer, Bahdışen
Cengiz, Mustafa
Source
International Journal of Analytical Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this study, amount of morphine from poppy capsules (Papaver somniferum) was investigated using ultrasonic assisted extraction (UAE).
Response surface methodology was used to estimate effective experimental conditions on the content extraction of poppy capsules.
For this purpose, solvent/solid ratio (10–20 mL/500 mg sample), pH (1–13), time (30–60 min), and temperature (30–50°C) were chosen as experimental variables.
The affected response is extraction recovery values for morphine from poppy straw.
For interpreting the relationship between experimental factors and response, a design table was established with combinations of three different concentrations levels of this compound in 29 trials.
The second order quadratic model gave a satisfactory description of the experimental data.
In our study, R-Squared (0.96), Adj-R-Squared (0.92), and Pred R-Squared (0.78) values for extraction yield display good accuracy of the derived model.
The predicted optimal conditions for the highest morphine level (3.38 mg morphine/500 mg-sample) were found at 19.99 mL solvent/500 mg solid ratio, 59.94 min extraction time, 1.10 pH, and 42.36°C temperature.
In the optimal extraction conditions, the experimental values are very close to the predicted values.
Consequently, the response surface modeling can be achieved sufficiently to predict extraction yield from poppy straw by ultrasound assisted extraction.
American Psychological Association (APA)
Bulduk, Ibrahim& Gezer, Bahdışen& Cengiz, Mustafa. 2015. Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064445
Modern Language Association (MLA)
Bulduk, Ibrahim…[et al.]. Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064445
American Medical Association (AMA)
Bulduk, Ibrahim& Gezer, Bahdışen& Cengiz, Mustafa. Optimization of Ultrasound-Assisted Extraction of Morphine from Capsules of Papaver somniferum by Response Surface Methodology. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064445