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PET Imaging of Epigenetic Influences on Alzheimer’s Disease
Joint Authors
Couto, Paul J.
Millis, Richard M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The precise role of environment-gene interactions (epigenetics) in the development and progression of Alzheimer’s disease (AD) is unclear.
This review focuses on the premise that radiotracer-specific PET imaging allows clinicians to visualize epigenetically influenced events and that such imaging may provide new, valuable insights for preventing, diagnosing, and treating AD.
Current understanding of the role of epigenetics in AD and the principles underlying the use of PET radiotracers for in vivo diagnosis are reviewed.
The relative efficacies of various PET radiotracers for visualizing the epigenetic influences on AD and their use for diagnosis are discussed.
For example, [18F]FAHA demonstrates sites of differential HDAC activity, [18F]FDG indirectly illuminates sites of neuronal hypomethylation, and the carbon-11 isotope-containing Pittsburgh compound B ([11C]PiB) images amyloid-beta plaque deposits.
A definitive AD diagnosis is currently achievable only by postmortem histological observation of amyloid-beta plaques and tau neurofibrillary tangles.
Therefore, reliable in vivo neuroimaging techniques could provide opportunities for early diagnosis and treatment of AD.
American Psychological Association (APA)
Couto, Paul J.& Millis, Richard M.. 2015. PET Imaging of Epigenetic Influences on Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064465
Modern Language Association (MLA)
Couto, Paul J.& Millis, Richard M.. PET Imaging of Epigenetic Influences on Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1064465
American Medical Association (AMA)
Couto, Paul J.& Millis, Richard M.. PET Imaging of Epigenetic Influences on Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1064465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064465