Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats
Joint Authors
Uche, Ndidi S.
Odunola, Oyeronke A.
Gbadegesin, Michael A.
Ibrahim, Mohammed A.
Sallau, Abdullahi B.
Aliyu, Muhammad
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats.
Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week.
The sodium arsenite and Acacia honey significantly P < 0.05 decreased AChE activity in the brain with the combined treatment being more potent.
Furthermore, sodium arsenite and Acacia honey significantly P < 0.05 decreased AChE activity in the serum.
Strong correlation was observed between the sodium and calcium ion levels with acetylcholinesterase activity in the brain and serum.
The gas chromatography mass spectrometry analysis of Acacia honey revealed the presence of a number of bioactive compounds such as phenolics, sugar derivatives, and fatty acids.
These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer’s diseases but this might be counteracted by the hepatotoxicity induced by arsenics.
American Psychological Association (APA)
Aliyu, Muhammad& Odunola, Oyeronke A.& Gbadegesin, Michael A.& Sallau, Abdullahi B.& Uche, Ndidi S.& Ibrahim, Mohammed A.. 2015. Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats. International Journal of Alzheimer's Disease،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064468
Modern Language Association (MLA)
Aliyu, Muhammad…[et al.]. Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats. International Journal of Alzheimer's Disease No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1064468
American Medical Association (AMA)
Aliyu, Muhammad& Odunola, Oyeronke A.& Gbadegesin, Michael A.& Sallau, Abdullahi B.& Uche, Ndidi S.& Ibrahim, Mohammed A.. Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats. International Journal of Alzheimer's Disease. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1064468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064468