Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans

Abstract EN

Purpose.

To investigate the regenerative results obtained with the association of bone marrow aspirate concentrate using the Bone Marrow Aspirate Concentrate (BMAC) method to a xenogeneic bone graft (Bio-Oss) in sinus floor elevation.

Materials and Methods.

Using a randomized controlled study design in eight consecutive patients (age of 55.4 ± 9.2 years), 16 sinus floor lift procedures were performed with Bio-Oss alone (control group, CG, n=8) or combined with bone marrow aspirate concentrate obtained via the BMAC method (test group, TG, n=8).

Six months after the grafting procedures, bone biopsies were harvested during implant placement and were analyzed by histomorphometry.

Results.

Histomorphometric analysis revealed a significantly higher amount (p<0.05) of vital mineralized tissue in TG when compared to the CG (55.15 ± 20.91% and 27.30 ± 5.55%, resp.).

For nonvital mineralized tissue, TG presented a statistically higher level of Bio-Oss resorption (p<0.05) when compared with the CG (6.32 ± 12.03% and 22.79 ± 9.60%, resp.).

Both groups (TG and CG) showed no significantly different levels (p>0.05) of nonmineralized tissue (38.53 ± 13.08% and 49.90 ± 7.64%, resp.).

Conclusion.

The use of bone marrow concentrate obtained by BMAC method increased bone formation in sinus lift procedures.