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Regulated Hyaluronan Synthesis by Vascular Cells
Joint Authors
Passi, Alberto
Caon, Ilaria
Karousou, Evgenia
Viola, Manuela
Vigetti, Davide
D'Angelo, Maria Luisa
De Luca, Giancarlo
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cellular microenvironment plays a critical role in several pathologies including atherosclerosis.
Hyaluronan (HA) content often reflects the progression of this disease in promoting vessel thickening and cell migration.
HA synthesis is regulated by several factors, including the phosphorylation of HA synthase 2 (HAS2) and other covalent modifications including ubiquitination and O-GlcNAcylation.
Substrate availability is important in HA synthesis control.
Specific drugs reducing the UDP precursors are able to reduce HA synthesis whereas the hexosamine biosynthetic pathway (HBP) increases the concentration of HA precursor UDP-N-acetylglucosamine (UDP-GlcNAc) leading to an increase of HA synthesis.
The flux through the HBP in the regulation of HA biosynthesis in human aortic vascular smooth muscle cells (VSMCs) was reported as a critical aspect.
In fact, inhibiting O-GlcNAcylation reduced HA production whereas increased O-GlcNAcylation augmented HA secretion.
Additionally, O-GlcNAcylation regulates HAS2 gene expression resulting in accumulation of its mRNA after induction of O-GlcNAcylation with glucosamine treatments.
The oxidized LDLs, the most common molecules related to atherosclerosis outcome and progression, are also able to induce a strong HA synthesis when they are in contact with vascular cells.
In this review, we present recent described mechanisms involved in HA synthesis regulation and their role in atherosclerosis outcome and development.
American Psychological Association (APA)
Viola, Manuela& Karousou, Evgenia& D'Angelo, Maria Luisa& Caon, Ilaria& De Luca, Giancarlo& Passi, Alberto…[et al.]. 2015. Regulated Hyaluronan Synthesis by Vascular Cells. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065319
Modern Language Association (MLA)
Viola, Manuela…[et al.]. Regulated Hyaluronan Synthesis by Vascular Cells. International Journal of Cell Biology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065319
American Medical Association (AMA)
Viola, Manuela& Karousou, Evgenia& D'Angelo, Maria Luisa& Caon, Ilaria& De Luca, Giancarlo& Passi, Alberto…[et al.]. Regulated Hyaluronan Synthesis by Vascular Cells. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065319