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Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery
Joint Authors
Kuhn, Liisa T.
Woodman, Jessica L.
Suh, Min Sung
Zhang, Jianxing
Kondaveeti, Yuvabharath
Burgess, Diane J.
White, Bruce A.
Prestwich, Glenn D.
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Carboxymethyl hyaluronic acid (CMHA) is a semisynthetic derivative of HA that is recognized by HA binding proteins but contains an additional carboxylic acid on some of the 6-hydroxyl groups of the N-acetyl glucosamine sugar units.
These studies tested the ability of CMHA to stabilize the formation of calcium phosphate nanoparticles and evaluated their potential to target therapy resistant, CD44+/CD24−/low human breast cancer cells (BT-474EMT).
CMHA stabilized particles (nCaPCMHA) were loaded with the chemotherapy drug cis-diamminedichloroplatinum(II) (CDDP) to form nCaPCMHACDDP.
nCaPCMHACDDP was determined to be poorly crystalline hydroxyapatite, 200 nm in diameter with a −43 mV zeta potential.
nCaPCMHACDDP exhibited a two-day burst release of CDDP that tapered resulting in 86% release by 7 days.
Surface plasmon resonance showed that nCaPCMHACDDP binds to CD44, but less effectively than CMHA or hyaluronan.
nCaPCMHA-AF488 was taken up by CD44+/CD24− BT-474EMT breast cancer cells within 18 hours.
nCaPCMHACDDP was as cytotoxic as free CDDP against the BT-474EMT cells.
Subcutaneous BT-474EMT tumors were more reproducibly inhibited by a near tumor dose of 2.8 mg/kg CDDP than a 7 mg/kg dose nCaPCMHACDDP.
This was likely due to a lack of distribution of nCaPCMHACDDP throughout the dense tumor tissue that limited drug diffusion.
American Psychological Association (APA)
Woodman, Jessica L.& Suh, Min Sung& Zhang, Jianxing& Kondaveeti, Yuvabharath& Burgess, Diane J.& White, Bruce A.…[et al.]. 2015. Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1065320
Modern Language Association (MLA)
Woodman, Jessica L.…[et al.]. Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery. International Journal of Cell Biology No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1065320
American Medical Association (AMA)
Woodman, Jessica L.& Suh, Min Sung& Zhang, Jianxing& Kondaveeti, Yuvabharath& Burgess, Diane J.& White, Bruce A.…[et al.]. Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1065320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065320