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Utilization of GlycosaminoglycansProteoglycans as Carriers for Targeted Therapy Delivery
Joint Authors
Misra, Suniti
Hascall, Vincent C.
Atanelishvili, Ilia
Moreno Rodriguez, Ricardo
Markwald, Roger R.
Ghatak, Shibnath
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture.
Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells.
In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling.
In particular this review describes how the glycosaminoglycan hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer.
American Psychological Association (APA)
Misra, Suniti& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo& Markwald, Roger R.& Ghatak, Shibnath. 2015. Utilization of GlycosaminoglycansProteoglycans as Carriers for Targeted Therapy Delivery. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1065329
Modern Language Association (MLA)
Misra, Suniti…[et al.]. Utilization of GlycosaminoglycansProteoglycans as Carriers for Targeted Therapy Delivery. International Journal of Cell Biology No. 2015 (2015), pp.1-25.
https://search.emarefa.net/detail/BIM-1065329
American Medical Association (AMA)
Misra, Suniti& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo& Markwald, Roger R.& Ghatak, Shibnath. Utilization of GlycosaminoglycansProteoglycans as Carriers for Targeted Therapy Delivery. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1065329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065329