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The Rise and Fall of Hyaluronan in Respiratory Diseases
Joint Authors
Garantziotis, Stavros
Lauer, Mark E.
Aronica, Mark A.
Dweik, Raed
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli.
Following pulmonary injury, elevated levels of HA matrices accumulate in these regions, and in respiratory secretions, correlating with the extent of injury.
Animal models have provided important insight into the role of HA in the onset of pulmonary injury and repair, generally indicating that the induction of HA synthesis is an early event typically preceding fibrosis.
The HA that accumulates in inflamed airways is of a high molecular weight (>1600 kDa) but can be broken down into smaller fragments (<150 kDa) by inflammatory and disease-related mechanisms that have profound effects on HA pathobiology.
During inflammation in the airways, HA is often covalently modified with heavy chains from inter-alpha-inhibitor via the enzyme tumor-necrosis-factor-stimulated-gene-6 (TSG-6) and this modification promotes the interaction of leukocytes with HA matrices at sites of inflammation.
The clearance of HA and its return to normal levels is essential for the proper resolution of inflammation.
These data portray HA matrices as an important component of normal airway physiology and illustrate its integral roles during tissue injury and repair among a variety of respiratory diseases.
American Psychological Association (APA)
Lauer, Mark E.& Dweik, Raed& Garantziotis, Stavros& Aronica, Mark A.. 2015. The Rise and Fall of Hyaluronan in Respiratory Diseases. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1065338
Modern Language Association (MLA)
Lauer, Mark E.…[et al.]. The Rise and Fall of Hyaluronan in Respiratory Diseases. International Journal of Cell Biology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1065338
American Medical Association (AMA)
Lauer, Mark E.& Dweik, Raed& Garantziotis, Stavros& Aronica, Mark A.. The Rise and Fall of Hyaluronan in Respiratory Diseases. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1065338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065338