Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model
Joint Authors
de la Motte, Carol A.
Kessler, Sean P.
Obery, Dana R.
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD).
Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the chemically induced dextran sodium sulfate (DSS) experimental colitis model, we previously determined that changes in colon distribution of HA occur before inflammation.
Therefore, we hypothesized that, during a pathologic challenge, HA promotes inflammation.
In this study, we tested the progression of inflammation in mice null for the hyaluronan synthase genes (HAS1, HAS3, or both HAS1 and HAS3) in the DSS-colitis model.
Our data demonstrate that both the HAS1/HAS3 double and the HAS3 null mice are protected from colitis, compared to wild-type and HAS1 null mice, as determined by measurement of weight loss, disease activity, serum IL-6 levels, histologic scoring, and immunohistochemistry.
Most notable is the dramatic increase in submucosal microvasculature, hyaluronan deposition, and leukocyte infiltration in the inflamed colon tissue of wild-type and HAS1 null mice.
Our data suggest, HAS3 plays a crucial role in driving gut inflammation.
Developing a temporary targeted therapeutic intervention of HAS3 expression or function in the microcirculation may emerge as a desirable strategy toward tempering colitis in patients undergoing flares of IBD.
American Psychological Association (APA)
Kessler, Sean P.& Obery, Dana R.& de la Motte, Carol A.. 2015. Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065340
Modern Language Association (MLA)
Kessler, Sean P.…[et al.]. Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model. International Journal of Cell Biology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1065340
American Medical Association (AMA)
Kessler, Sean P.& Obery, Dana R.& de la Motte, Carol A.. Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065340