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Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer
Joint Authors
Shiina, Marisa
Bourguignon, Lilly Y. W.
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We determined that human head and neck cancer cells (HSC-3 cell line) contain a subpopulation displaying cancer stem cell (CSC) properties and are very tumorigenic.
Specifically, we investigated whether different sizes of hyaluronan (HA) (e.g., 5 kDa, 20 kDa, 200 kDa, or 700 kDa-HA-sizes) play a role in regulating these CSCs.
First, we observed that 200 kDa-HA (but not other sizes of HA) preferentially induces certain stem cell marker expression resulting in self-renewal and clonal formation of these cells.
Further analyses indicate that 200 kDa-HA selectively stimulates the expression of a panel of microRNAs (most noticeably miR-10b) in these CSCs.
Survival protein (cIAP-1) expression was also stimulated by 200 kDa-HA in these CSCs leading to cisplatin resistance.
Furthermore, our results indicate that the anti-miR-10 inhibitor not only decreases survival protein expression, but also increases chemosensitivity of the 200 kDa-HA-treated CSCs.
These findings strongly support the contention that 200 kDa-HA plays a pivotal role in miR-10 production leading to survival protein upregulation and chemoresistance in CSCs.
Together, our findings suggest that selective activation of oncogenic signaling by certain sizes of HA (e.g., 200 kDa-HA) may be instrumental in the formation of CSC functions leading to tumor cell survival and chemoresistance in head and neck cancer progression.
American Psychological Association (APA)
Shiina, Marisa& Bourguignon, Lilly Y. W.. 2015. Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065363
Modern Language Association (MLA)
Shiina, Marisa& Bourguignon, Lilly Y. W.. Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer. International Journal of Cell Biology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065363
American Medical Association (AMA)
Shiina, Marisa& Bourguignon, Lilly Y. W.. Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065363