Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium
Joint Authors
Lukandu, Ochiba Mohammed
Koech, Lionel Sang
Kiarie, Paul Ngugi
Source
International Journal of Dentistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
The habit of khat chewing is prevalent in many Middle Eastern and African cultures and has been associated with various adverse conditions in humans.
This study aimed to describe histological changes induced by chronic khat chewing on the buccal mucosa.
Methods.
Biopsies of the buccal mucosa from 14 chronic khat chewers, 20 chronic khat chewers who also smoked tobacco, and 8 nonchewers were compared for epithelial thickness, degree and type of keratinization, and connective tissue changes.
Results.
Tissues from khat chewers depicted abnormal keratinization of the superficial cell layer and showed increased epithelial thickness affecting all layers.
Epithelial thickness in control samples was 205 ± 26 μm whereas thickness in khat chewers and khat chewers who smoked tobacco was significantly higher measuring 330 ± 35 μm and 335 ± 19 μm, respectively.
Tissues from khat chewers also showed increased intracellular edema, increased melanin pigment deposits, and increased number of rete pegs most of which were thin and deep.
Conclusions.
These results show that oral lesions induced by chronic chewing of khat in the buccal mucosa present with white and brown discoloration due to increased epithelial thickness, increased keratinization, and melanin deposition.
American Psychological Association (APA)
Lukandu, Ochiba Mohammed& Koech, Lionel Sang& Kiarie, Paul Ngugi. 2015. Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium. International Journal of Dentistry،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065421
Modern Language Association (MLA)
Lukandu, Ochiba Mohammed…[et al.]. Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium. International Journal of Dentistry No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065421
American Medical Association (AMA)
Lukandu, Ochiba Mohammed& Koech, Lionel Sang& Kiarie, Paul Ngugi. Oral Lesions Induced by Chronic Khat Use Consist Essentially of Thickened Hyperkeratinized Epithelium. International Journal of Dentistry. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065421