The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis
Joint Authors
Yee, Sung-Tae
Kim, Kwang-Jin
Choi, Kyung-Hee
Leutou, Alain Simplice
Yeon, Jeong-Tae
Nam, Sang-Jip
Kim, Seong Hwan
Choi, Sik-Won
Son, Young-Jin
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Osteoporosis is a disease that decreases bone mass.
The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs.
Osteoporosis treatment is all-important in preventing bone loss.
One strategy for osteoporosis treatment is to inhibit osteoclastogenesis.
Osteoclasts are bone-resorbing multinucleated cells, and overactive osteoclasts and/or their increased number are observed in bone disorders including osteoporosis and rheumatoid arthritis.
Bioactivity-guided fractionations led to the isolation of alisol A 24-acetate from the dried tuber of Alisma canaliculatum.
Alisol A 24-acetate inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1, which plays an essential role in osteoclast differentiation.
Furthermore, it inhibited the expression of DC-STAMP and cathepsin K, which are related to cell-cell fusion of osteoclasts and bone resorption, respectively.
Therefore, alisol A 24-acetate could be developed as a new structural scaffold for inhibitors of osteoclast differentiation in order to develop new drugs against osteoporosis.
American Psychological Association (APA)
Kim, Kwang-Jin& Leutou, Alain Simplice& Yeon, Jeong-Tae& Choi, Sik-Won& Kim, Seong Hwan& Yee, Sung-Tae…[et al.]. 2015. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065560
Modern Language Association (MLA)
Kim, Kwang-Jin…[et al.]. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065560
American Medical Association (AMA)
Kim, Kwang-Jin& Leutou, Alain Simplice& Yeon, Jeong-Tae& Choi, Sik-Won& Kim, Seong Hwan& Yee, Sung-Tae…[et al.]. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065560