Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus
Joint Authors
Abdalla, Dulcinéia Saes
Pereira, Edimar Cristiano
Bertolami, Marcelo Chiara
Faludi, André Arpad
Monte, Osmar
Xavier, Hermes Toros
Pereira, Tiago Veiga
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the potential of a panel of 22 biomarkers to predict the presence of coronary artery disease (CAD) in type 2 diabetes mellitus (DM2) patients.
The study enrolled 96 DM2 patients with (n = 75) and without (n = 21) evidence of CAD.
We assessed a biochemical profile that included 22 biomarkers: total cholesterol, LDL, HDL, LDL/HDL, triglycerides, glucose, glycated hemoglobin, fructosamine, homocysteine, cysteine, methionine, reduced glutathione, oxidized glutathione, reduced glutathione/oxidized glutathione, L-arginine, asymmetric dimethyl-L-arginine, symmetric dimethyl-L-arginine, asymmetric dimethyl-L-arginine/L-arginine, nitrate plus nitrite, S-nitrosothiols, nitrotyrosine, and n-acetyl-β-glucosaminidase.
Prediction models were built using logistic regression models.
We found that eight biomarkers (methionine, nitratate plus nitrite, n-acetyl-β-glucosaminidase, BMI, LDL, HDL, reduced glutathione, and L-arginine/asymmetric dimethyl-L-arginine) along with gender and BMI were significantly associated with the odds of CAD in DM2.
These preliminary findings support the notion that emerging biochemical markers might be used for CAD prediction in patients with DM2.
Our findings warrant further investigation with large, well-designed studies.
American Psychological Association (APA)
Pereira, Edimar Cristiano& Bertolami, Marcelo Chiara& Faludi, André Arpad& Monte, Osmar& Xavier, Hermes Toros& Pereira, Tiago Veiga…[et al.]. 2015. Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065565
Modern Language Association (MLA)
Pereira, Edimar Cristiano…[et al.]. Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065565
American Medical Association (AMA)
Pereira, Edimar Cristiano& Bertolami, Marcelo Chiara& Faludi, André Arpad& Monte, Osmar& Xavier, Hermes Toros& Pereira, Tiago Veiga…[et al.]. Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065565