The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)
Joint Authors
Midthjell, Kristian
Helgeland, Øyvind
Hertel, Jens K.
Molven, Anders
Ræder, Helge
Platou, Carl G. P.
Hveem, Kristian
Nygård, Ottar
Njølstad, Pål R.
Johansson, Stefan
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD).
The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed.
By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2.
Results.
Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282∣rs10811661: OR = 1.19, P=2.0×10-3) in the region.
We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD (P<0.01).
Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501 (P=0.03) and rs3217986 (P=0.04).
Conclusions.
We confirmed the association of known variants within the 9p21 interval with T2D and CHD.
Our results further suggest that additional CHD susceptibility variants exist in this region.
American Psychological Association (APA)
Helgeland, Øyvind& Hertel, Jens K.& Molven, Anders& Ræder, Helge& Platou, Carl G. P.& Midthjell, Kristian…[et al.]. 2015. The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey). International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065575
Modern Language Association (MLA)
Helgeland, Øyvind…[et al.]. The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey). International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065575
American Medical Association (AMA)
Helgeland, Øyvind& Hertel, Jens K.& Molven, Anders& Ræder, Helge& Platou, Carl G. P.& Midthjell, Kristian…[et al.]. The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey). International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065575