Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes
Author
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Zinc is an essential trace element that plays a vital role in many biological processes including growth and development, immunity, and metabolism.
Recent studies have highlighted zinc’s dynamic role as a “cellular second messenger” in the control of insulin signaling and glucose homeostasis.
Accordingly, mechanisms that contribute to dysfunctional zinc signaling are suggested to be associated with metabolic disease states including cancer, cardiovascular disease, Alzheimer’s disease, and diabetes.
The actions of the proteins that control the uptake, storage, and distribution of zinc, the zinc transporters, are under intense investigation due to their emerging role in type 2 diabetes.
The synthesis, secretion, and action of insulin are dependent on zinc and the transporters that make this ion available to cellular processes.
This suggests that zinc plays a previously unidentified role where changes in zinc status over time may affect insulin activity.
This previously unexplored concept would raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy.
American Psychological Association (APA)
Myers, Stephen A.. 2015. Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065578
Modern Language Association (MLA)
Myers, Stephen A.. Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065578
American Medical Association (AMA)
Myers, Stephen A.. Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065578