Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren
Joint Authors
Chu, Nain-Feng
Chen, Jin-Shuen
Pei, Dee
Wu, Chung-Ze
Lin, Yuh-Feng
Chang, Li-Chien
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren.
We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei.
Anthropometry, fibrinolytic proteins, MetS components, insulin secretion, and resistance were measured.
Subjects were divided into normal, overweight, and obese groups.
Finally, the relationship between fibrinolytic proteins and metabolic syndrome in boys and girls was analyzed.
In boys, PAI-1 was positively associated with body mass index (BMI) percentile, hypertriglyceride, insulin secretion, and resistance.
In girls, PAI-1 was positively associated with obesity, hypertriglyceridemia, and insulin secretion.
In girls, uPA was positively associated with insulin secretion.
suPAR was positively associated with high-sensitivity C-reactive protein in both boys and girls, and with BMI percentile and body fat in girls.
The obese boys had higher suPAR and PAI-1 levels than the normal group.
The obese girls had higher uPA, suPAR, and PAI-1 than the normal group.
Boys and girls with MetS had higher PAI-1.
Fibrinolytic proteins, especially PAI-1, are associated with MetS components and insulin secretion in children.
Fibrinolytic proteins changes were more likely to occur in girls than in boys.
American Psychological Association (APA)
Chen, Jin-Shuen& Wu, Chung-Ze& Chu, Nain-Feng& Chang, Li-Chien& Pei, Dee& Lin, Yuh-Feng. 2015. Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065580
Modern Language Association (MLA)
Chen, Jin-Shuen…[et al.]. Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065580
American Medical Association (AMA)
Chen, Jin-Shuen& Wu, Chung-Ze& Chu, Nain-Feng& Chang, Li-Chien& Pei, Dee& Lin, Yuh-Feng. Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065580