Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer
Joint Authors
Marcello, Marjory Alana
Carvalho, André Lopes
Martins, Mariana Bonjiorno
Calixto, Antonio Ramos
de Almeida, Jacqueline Fatima Martins
Cavalari, Camila Ayume Amano
Etchebehere, Elba C. S.
Assumpção, Ligia Vera Montalli da
Geloneze, Bruno
Ward, Laura Sterian
Cunha, Lucas Leite
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels.
Methods.
We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC.
Results.
Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22±0.98 ng/mL) than those with AG genotype (10.07±0.60 ng/mL; P=0.005).
Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05±0.59 ng/mL) than the subjects with GG genotype (9.52±0.79 ng/mL; P<0.05).
A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689; P=0.0183; 95% CI, 1.516–90.119).
Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747; P=0.027; 95% CI, 1.161–12.092 and OR, 5.437; P=0.013; 95% CI, 1.426–20.729).
Conclusions.
We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC.
Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness.
American Psychological Association (APA)
Marcello, Marjory Alana& Calixto, Antonio Ramos& de Almeida, Jacqueline Fatima Martins& Martins, Mariana Bonjiorno& Cunha, Lucas Leite& Cavalari, Camila Ayume Amano…[et al.]. 2015. Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065581
Modern Language Association (MLA)
Marcello, Marjory Alana…[et al.]. Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065581
American Medical Association (AMA)
Marcello, Marjory Alana& Calixto, Antonio Ramos& de Almeida, Jacqueline Fatima Martins& Martins, Mariana Bonjiorno& Cunha, Lucas Leite& Cavalari, Camila Ayume Amano…[et al.]. Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065581