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The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation
Joint Authors
Lee, Chien-Hsing
Hsiao, Fone-Ching
Hsieh, Po-Shiuan
Wu, Kuo-Sheng
Hung, Yi-Jen
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells.
GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes.
The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type.
While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity.
Accordingly, the participation of GAS6 in the progression of obesity remains controversial.
In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders.
In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications.
American Psychological Association (APA)
Wu, Kuo-Sheng& Hung, Yi-Jen& Lee, Chien-Hsing& Hsiao, Fone-Ching& Hsieh, Po-Shiuan. 2015. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065587
Modern Language Association (MLA)
Wu, Kuo-Sheng…[et al.]. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065587
American Medical Association (AMA)
Wu, Kuo-Sheng& Hung, Yi-Jen& Lee, Chien-Hsing& Hsiao, Fone-Ching& Hsieh, Po-Shiuan. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065587