Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes
Joint Authors
Wu, Jingcheng
Li, Xiaohua
Tao, Yang
Wang, Yufei
Peng, Yongde
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the association of thyroid function and diabetic nephropathy (DN) in euthyroid patients with type 2 diabetes.
Methods.
A total of 421 patients were included in this cross-sectional study.
The following parameters were assessed: anthropometric measurements, fast plasma glucose, serum creatinine, lipid profile, HbA1c, free triiodothyronine (FT3), free thyroxine, thyroid-stimulating hormone levels, and urinary albumin-to-creatinine ratio (UACR).
Patients with UACR of ≥30 mg/g were defined as those suffering from DN.
Results.
Of the 421 patients, 203 (48.2%) suffered from DN, and no difference was found between males and females.
The patients with DN yielded significantly lower FT3 levels than those without DN (P<0.01).
The prevalence of DN showed a significantly decreasing trend across the three tertiles based on FT3 levels (59.6%, 46.4%, and 38.6%, P<0.01).
After adjustment for gender and age, FT3 levels were found to correlate positively with estimated glomerular filtration rate (P=0.03) and negatively with UACR (P<0.01).
Multiple linear regression analysis showed that FT3 level was independently associated with UACR (β=-0.18, t=-3.70, and P<0.01).
Conclusion.
Serum FT3 levels are inversely associated with DN in euthyroid patients with type 2 diabetes, independent of traditional risk factors.
American Psychological Association (APA)
Wu, Jingcheng& Li, Xiaohua& Tao, Yang& Wang, Yufei& Peng, Yongde. 2015. Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065588
Modern Language Association (MLA)
Wu, Jingcheng…[et al.]. Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065588
American Medical Association (AMA)
Wu, Jingcheng& Li, Xiaohua& Tao, Yang& Wang, Yufei& Peng, Yongde. Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065588