Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy
Joint Authors
Lee, Su Mi
An, Won Suk
Chung, Seuk Hee
Park, Yongjin
Park, Mi Kyoung
Son, Young Ki
Kim, Seong Eun
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetic nephropathy is the leading cause of end-stage renal disease and is associated with an increased risk of cardiovascular events.
Dietary omega-3 fatty acid (FA) has cardioprotective effect and is associated with a slower deterioration of albumin excretion in patients with diabetic nephropathy.
In this study, we evaluated the effect of omega-3 FA on proteinuria in diabetic nephropathy patients who are controlling blood pressure (BP) with angiotensin converting enzyme inhibitor (ACEi) or angiotensin II receptor blocker (ARB).
In addition, we identified changes in erythrocyte membrane FA contents.
A total of 19 patients who were treated with ACEi or ARB for at least 6 months were treated for 12 weeks with omega-3 FA (Omacor, 3 g/day) or a control treatment (olive oil, 3 g/day).
Proteinuria levels were unchanged after 12 weeks compared with baseline values in both groups.
The erythrocyte membrane contents of omega-3 FA and eicosapentaenoic acid (EPA) were significantly increased, and oleic acid, arachidonic acid : EPA ratio, and omega-6 : omega-3 FA ratio were significantly decreased after 12 weeks compared with the baseline values in the omega-3 FA group.
Although omega-3 FA did not appear to alter proteinuria, erythrocyte membrane FA contents, including oleic acid, were altered by omega-3 FA supplementation.
American Psychological Association (APA)
Lee, Su Mi& Chung, Seuk Hee& Park, Yongjin& Park, Mi Kyoung& Son, Young Ki& Kim, Seong Eun…[et al.]. 2015. Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065590
Modern Language Association (MLA)
Lee, Su Mi…[et al.]. Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065590
American Medical Association (AMA)
Lee, Su Mi& Chung, Seuk Hee& Park, Yongjin& Park, Mi Kyoung& Son, Young Ki& Kim, Seong Eun…[et al.]. Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065590