High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes
Joint Authors
Guerranti, Cristiana
Bruzzi, Patrizia
Perra, Guido
Focardi, Silvano E.
Iughetti, Lorenzo
Predieri, Barbara
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Impairments of endocrine system may be associated with exposure to perfluorinated compounds that are able to bind nuclear receptors, including the peroxisome proliferator-activating receptors.
Aim of this study was to assess perfluorooctane sulfonate and perfluorooctanoic acid concentrations in children and adolescents at the onset of type 1 diabetes compared to healthy controls.
Methods.
Forty-four children and adolescents were recruited and subdivided into two groups: (A) 25 subjects with type 1 diabetes and (B) 19 healthy controls.
Perfluorinated compounds were measured using high performance liquid chromatography with electrospray ionization tandem mass spectrometry.
Nonparametric statistical analysis was performed.
Results.
Perfluorooctane sulfonate concentrations were significantly higher in patients with type 1 diabetes compared to controls (1.53 ± 1.50 versus 0.55 ± 0.15 ng/mL, resp.; p<0.001).
Multivariate linear regression analysis identified lipid levels as significant predictive factors for perfluorooctane sulfonate levels.
Conclusions.
Our data suggests that higher serum levels of perfluorooctane sulfonate may be considered a biomarker of exposure and susceptibility to develop type 1 diabetes.
American Psychological Association (APA)
Predieri, Barbara& Iughetti, Lorenzo& Guerranti, Cristiana& Bruzzi, Patrizia& Perra, Guido& Focardi, Silvano E.. 2015. High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065598
Modern Language Association (MLA)
Predieri, Barbara…[et al.]. High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065598
American Medical Association (AMA)
Predieri, Barbara& Iughetti, Lorenzo& Guerranti, Cristiana& Bruzzi, Patrizia& Perra, Guido& Focardi, Silvano E.. High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065598