MicroNanostructures and Mechanical Properties of Trabecular Bone in Ovariectomized Rats
Joint Authors
Wu, Xian-Ping
Dai, Ru-Chun
Hu, Shidi
Li, Jin
Liu, Lu
Sheng, Zhifeng
Feng, Xiqiao
Yao, Xuefeng
Keller, Evan
Jiang, Yebin
Liao, Er-Yuan
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bone mechanical properties encompass both geometric and material factors, while the effects of estrogen deficiency on the material and structural characteristics of bone at micro- to nanoscales are still obscure.
We performed a series of combined methodological experiments, including nanoindentation assessment of intrinsic material properties, atomic force microscopy (AFM) characterization of trabecular (Tb) nanostructure, and Tb microarchitecture and 2D BMD.
At 15 weeks after surgery, we found significantly less Tb bone mineral density (BMD) at organ (−27%) and at tissue level (−12%), Tb bone volume fraction (−29%), Tb thickness (−14%), and Tb number (−17%) in ovariectomy (OVX) rats than in sham operated (SHAM) rats, while the structure model index (+91%) and Tb separation (+19%) became significantly greater.
AFM images showed lower roughness Tb surfaces with loosely packed large nodular structures and less compacted interfibrillar space in OVX than in SHAM.
However, no statistically significant changes were in the Tb intrinsic material properties—nanoindentation hardness, elastic modulus, and plastic deformation—nanoindentation depths, and residual areas.
Therefore, estrogen deprivation results in a dramatic deterioration in Tb micro/nanoarchitectures, 3D volumetric BMD at both organ and tissue levels, and 2D BMD, but not in the nanomechanical properties of the trabeculae per se.
American Psychological Association (APA)
Hu, Shidi& Li, Jin& Liu, Lu& Dai, Ru-Chun& Sheng, Zhifeng& Wu, Xian-Ping…[et al.]. 2015. MicroNanostructures and Mechanical Properties of Trabecular Bone in Ovariectomized Rats. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065606
Modern Language Association (MLA)
Hu, Shidi…[et al.]. MicroNanostructures and Mechanical Properties of Trabecular Bone in Ovariectomized Rats. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065606
American Medical Association (AMA)
Hu, Shidi& Li, Jin& Liu, Lu& Dai, Ru-Chun& Sheng, Zhifeng& Wu, Xian-Ping…[et al.]. MicroNanostructures and Mechanical Properties of Trabecular Bone in Ovariectomized Rats. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065606