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Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease
Joint Authors
Kalyoncu, Derya
Urganci, Nafiye
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD).
Methods.
67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up.
Results.
None of the patients had antithyroid antibodies at diagnosis.
Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD.
Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%).
The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD ( P > 0.05 ).
A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies ( P = 0.004 ).
None of the patients had any change in their thyroid function and antibody profile during their follow-up.
Conclusion.
Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake.
American Psychological Association (APA)
Kalyoncu, Derya& Urganci, Nafiye. 2015. Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1065610
Modern Language Association (MLA)
Kalyoncu, Derya& Urganci, Nafiye. Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease. International Journal of Endocrinology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1065610
American Medical Association (AMA)
Kalyoncu, Derya& Urganci, Nafiye. Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1065610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065610