The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
Joint Authors
Krist, Bart
Florczyk, Urszula
Pietraszek-Gremplewicz, Katarzyna
Józkowicz, Alicja
Dulak, Jozef
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level.
Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β.
Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration.
On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors.
In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion.
This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation.
American Psychological Association (APA)
Krist, Bart& Florczyk, Urszula& Pietraszek-Gremplewicz, Katarzyna& Józkowicz, Alicja& Dulak, Jozef. 2015. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065613
Modern Language Association (MLA)
Krist, Bart…[et al.]. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology. International Journal of Endocrinology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1065613
American Medical Association (AMA)
Krist, Bart& Florczyk, Urszula& Pietraszek-Gremplewicz, Katarzyna& Józkowicz, Alicja& Dulak, Jozef. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065613