The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones
Joint Authors
De Vita, Francesca
Ticinesi, Andrea
Ceda, Gian Paolo
Maggio, Marcello
Fisichella, Alberto
Ceresini, Graziano
Cappola, Anne
Ferrucci, Luigi
Lauretani, Fulvio
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Anemia is a multifactorial condition whose prevalence increases in both sexes after the fifth decade of life.
It is a highly represented phenomenon in older adults and in one-third of cases is “unexplained.” Ageing process is also characterized by a “multiple hormonal dysregulation” with disruption in gonadal, adrenal, and somatotropic axes.
Experimental studies suggest that anabolic hormones such as testosterone, IGF-1, and thyroid hormones are able to increase erythroid mass, erythropoietin synthesis, and iron bioavailability, underlining a potential role of multiple hormonal changes in the anemia of aging.
Epidemiological data more consistently support an association between lower testosterone and anemia in adult-older individuals.
Low IGF-1 has been especially associated with anemia in the pediatric population and in a wide range of disorders.
There is also evidence of an association between thyroid hormones and abnormalities in hematological parameters under overt thyroid and euthyroid conditions, with limited data on subclinical statuses.
Although RCTs have shown beneficial effects, stronger for testosterone and the GH-IGF-1 axis and less evident for thyroid hormones, in improving different hematological parameters, there is no clear evidence for the usefulness of hormonal treatment in improving anemia in older subjects.
Thus, more clinical and research efforts are needed to investigate the hormonal contribution to anemia in the older individuals.
American Psychological Association (APA)
Maggio, Marcello& De Vita, Francesca& Fisichella, Alberto& Lauretani, Fulvio& Ticinesi, Andrea& Ceresini, Graziano…[et al.]. 2015. The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1065620
Modern Language Association (MLA)
Maggio, Marcello…[et al.]. The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones. International Journal of Endocrinology No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1065620
American Medical Association (AMA)
Maggio, Marcello& De Vita, Francesca& Fisichella, Alberto& Lauretani, Fulvio& Ticinesi, Andrea& Ceresini, Graziano…[et al.]. The Role of the Multiple Hormonal Dysregulation in the Onset of “Anemia of Aging”: Focus on Testosterone, IGF-1, and Thyroid Hormones. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1065620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065620