Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The liver is one of the most essential organs involved in the regulation of energy homeostasis.
Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion.
Epidemiological studies show sex difference in the prevalence in fatty liver disease and suggest that sex hormones may play vital roles in regulating hepatic steatosis.
In this review, we summarize current literature and discuss the role of estrogens and androgens and the mechanisms through which estrogen receptors and androgen receptors regulate lipid and glucose metabolism in the liver.
In females, estradiol regulates liver metabolism via estrogen receptors by decreasing lipogenesis, gluconeogenesis, and fatty acid uptake, while enhancing lipolysis, cholesterol secretion, and glucose catabolism.
In males, testosterone works via androgen receptors to increase insulin receptor expression and glycogen synthesis, decrease glucose uptake and lipogenesis, and promote cholesterol storage in the liver.
These recent integrated concepts suggest that sex hormone receptors could be potential promising targets for the prevention of hepatic steatosis.
American Psychological Association (APA)
Shen, Minqian& Shi, Haifei. 2015. Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065621
Modern Language Association (MLA)
Shen, Minqian& Shi, Haifei. Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. International Journal of Endocrinology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1065621
American Medical Association (AMA)
Shen, Minqian& Shi, Haifei. Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1065621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065621