Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer.
Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle.
Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.
American Psychological Association (APA)
Her, Yeng F.& Maher, L. James. 2015. Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1065622
Modern Language Association (MLA)
Her, Yeng F.& Maher, L. James. Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics. International Journal of Endocrinology No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1065622
American Medical Association (AMA)
Her, Yeng F.& Maher, L. James. Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1065622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065622