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Identification of Intermediate- to High-Risk Papillary Thyroid Carcinoma Patients Who May Be Safely Managed without the Performance of Delayed Stimulated Thyroglobulin Measurements following Total Thyroidectomy and Radioactive Iodine Therapy
Joint Authors
Bae, Ja-Seong
Kim, Kyung-Hee
Kim, Min-Hee
Lim, Ye-Jee
Lee, Ihn Suk
Lim, Dong-Jun
Lee, Jong Min
Kang, Moo-Il
Cha, Bong-Yun
Baek, Ki-Hyun
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The measurement of stimulated thyroglobulin (sTg) after total thyroidectomy and remnant radioactive iodine (RAI) ablation is the gold standard for monitoring disease status in patients with papillary thyroid carcinomas (PTCs).
The aim of this study was to determine whether sTg measurement during follow-up can be avoided in intermediate- and high-risk PTC patients.
Methods.
A total of 346 patients with PTCs with an intermediate or high risk of recurrence were analysed.
All of the patients underwent total thyroidectomy as well as remnant RAI ablation and sTg measurements.
Preoperative and postoperative parameters were included in the analysis.
Results.
Among the preoperative parameters, age below 45 years and preoperative Tg above 19.4 ng/mL were significant risk factors for predicting detectable sTg during follow-up.
Among the postoperative parameters, thyroid capsular invasion, lymph node metastasis, and ablative Tg above 2.9 ng/mL were independently correlated with a detectable sTg range.
The combination of ablative Tg less than 2.9 ng/mL with pre- and postoperative independent risk factors for detectable sTg increased the negative predictive value for detectable sTg up to 98.5%.
Conclusions.
Based on pre- and postoperative parameters, a substantial proportion of patients with PTCs in the intermediate- and high-risk classes could avoid aggressive follow-up measures.
American Psychological Association (APA)
Kim, Kyung-Hee& Kim, Min-Hee& Lim, Ye-Jee& Lee, Ihn Suk& Bae, Ja-Seong& Lim, Dong-Jun…[et al.]. 2015. Identification of Intermediate- to High-Risk Papillary Thyroid Carcinoma Patients Who May Be Safely Managed without the Performance of Delayed Stimulated Thyroglobulin Measurements following Total Thyroidectomy and Radioactive Iodine Therapy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065633
Modern Language Association (MLA)
Kim, Kyung-Hee…[et al.]. Identification of Intermediate- to High-Risk Papillary Thyroid Carcinoma Patients Who May Be Safely Managed without the Performance of Delayed Stimulated Thyroglobulin Measurements following Total Thyroidectomy and Radioactive Iodine Therapy. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065633
American Medical Association (AMA)
Kim, Kyung-Hee& Kim, Min-Hee& Lim, Ye-Jee& Lee, Ihn Suk& Bae, Ja-Seong& Lim, Dong-Jun…[et al.]. Identification of Intermediate- to High-Risk Papillary Thyroid Carcinoma Patients Who May Be Safely Managed without the Performance of Delayed Stimulated Thyroglobulin Measurements following Total Thyroidectomy and Radioactive Iodine Therapy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065633