Ejaculate Oxidative Stress Is Related with Sperm DNA Fragmentation and Round Cells
Joint Authors
Iommiello, Valeria Maria
Albani, Elena
Di Rosa, Alessandra
Marras, Alessandra
Menduni, Francesca
Morreale, Giovanna
Levi, Shanti Lia
Pisano, Benedetta
Levi-Setti, Paolo Emanuele
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oxidative stress (OS) plays an essential role in male infertility aetiology by affecting sperm quality, function, and also the integrity of sperm DNA.
The assessment of oxidative stress in semen may be an important tool to improve the evaluation of sperm reproductive capacity.
The purpose of this study was the evaluation of any possible relation between the unbalance of oxidative stress caused by superoxide anion in the ejaculate with the presence of sperm DNA fragmentation and high concentration of round cells.
56 semen samples from males from couples suffering from infertility were evaluated according to World Health Organisation (WHO) 2010 guidelines.
Oxidative stress levels from N1 (low) to N4 (high) were assessed in ejaculates using oxiSperm; DFI (sperm DNA fragmentation index) as assessed by the SCSA (Sperm Chromatin Structure Assay) was used for evaluation of sperm chromatin integrity.
Our data show that high oxidative stress (N3-N4 levels) correlated positively with a DFI≥30% (P=0.0379) and round cells ≥1.500.000/mL (P=0.0084).
In conclusion, OS increases sperm DNA damage.
Thus evaluation of semen OS extent of sperm DNA damage in infertile man could be useful to develop new therapeutic strategies and improve success of assisted reproductiontechniques (ART).
American Psychological Association (APA)
Iommiello, Valeria Maria& Albani, Elena& Di Rosa, Alessandra& Marras, Alessandra& Menduni, Francesca& Morreale, Giovanna…[et al.]. 2015. Ejaculate Oxidative Stress Is Related with Sperm DNA Fragmentation and Round Cells. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065636
Modern Language Association (MLA)
Iommiello, Valeria Maria…[et al.]. Ejaculate Oxidative Stress Is Related with Sperm DNA Fragmentation and Round Cells. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065636
American Medical Association (AMA)
Iommiello, Valeria Maria& Albani, Elena& Di Rosa, Alessandra& Marras, Alessandra& Menduni, Francesca& Morreale, Giovanna…[et al.]. Ejaculate Oxidative Stress Is Related with Sperm DNA Fragmentation and Round Cells. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065636