Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes
Joint Authors
Huang, Jui-Hua
Cheng, Fu-Chou
Wu, Hsu-Chen
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study is to investigate the impact of serum Mg on bone mineral metabolism in chronic kidney disease (CKD) patients with or without diabetes.
A total of 56 CKD patients not receiving dialysis were recruited and divided into two groups, one group of 27 CKD patients with diabetes and another group of 29 CKD patients without diabetes.
Biochemical determinations were made, and the estimated glomerular filtration rate (eGFR) was measured.
Bone mineral density was measured by dual-energy X-ray absorptiometry.
Serum Mg was inversely correlated with serum Ca P=0.023 and positively correlated with serum parathyroid hormone (PTH) P=0.020, alkaline phosphatase P=0.044, and phosphate P=0.040 in the CKD patients with diabetes.
The CKD patients with diabetes had lower serum albumin and a higher proportion of hypomagnesemia and osteoporosis than the nondiabetic patients did P<0.05.
Serum Mg was inversely correlated with eGFR in the CKD patients with or without diabetes P<0.05.
Serum Mg showed an inverse correlation with 25-hydroxyvitamin D in CKD patients without diabetes P=0.006.
Furthermore, the diabetic CKD patients with low serum Mg had a lower iPTH P=0.007 and a higher serum Ca/Mg ratio P<0.001 than the other CKD patients.
The lower serum Mg subgroup showed a higher incidence of osteoporosis than the moderate and higher serum Mg subgroups did (66.7%, 39.4%, and 29.4%, resp.).
In conclusion, low serum Mg may impact iPTH and exacerbates osteoporosis in CKD patients, particularly with diabetes.
American Psychological Association (APA)
Huang, Jui-Hua& Cheng, Fu-Chou& Wu, Hsu-Chen. 2015. Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065672
Modern Language Association (MLA)
Huang, Jui-Hua…[et al.]. Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065672
American Medical Association (AMA)
Huang, Jui-Hua& Cheng, Fu-Chou& Wu, Hsu-Chen. Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065672