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Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer
Joint Authors
McBeth, Lucien
Grabnar, Maria
Selman, Steven
Hinds, Terry D.
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors.
The disease has a male to female prevalence of 3 : 1.
This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer.
Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis.
Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer.
The glucocorticoid receptor- (GR-) α isoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer.
In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth.
In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.
American Psychological Association (APA)
McBeth, Lucien& Grabnar, Maria& Selman, Steven& Hinds, Terry D.. 2015. Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065679
Modern Language Association (MLA)
McBeth, Lucien…[et al.]. Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065679
American Medical Association (AMA)
McBeth, Lucien& Grabnar, Maria& Selman, Steven& Hinds, Terry D.. Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065679