Antifibrotic Activity of Acylated and Unacylated Ghrelin
Joint Authors
Angelino, Elia
Reano, Simone
Ferrara, Michele
Agosti, Emanuela
Graziani, Andrea
Filigheddu, Nicoletta
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed.
Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix.
Acylated and unacylated ghrelin are the main products of the ghrelin gene.
The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release.
Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities.
Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis.
The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic.
American Psychological Association (APA)
Angelino, Elia& Reano, Simone& Ferrara, Michele& Agosti, Emanuela& Graziani, Andrea& Filigheddu, Nicoletta. 2015. Antifibrotic Activity of Acylated and Unacylated Ghrelin. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065684
Modern Language Association (MLA)
Angelino, Elia…[et al.]. Antifibrotic Activity of Acylated and Unacylated Ghrelin. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065684
American Medical Association (AMA)
Angelino, Elia& Reano, Simone& Ferrara, Michele& Agosti, Emanuela& Graziani, Andrea& Filigheddu, Nicoletta. Antifibrotic Activity of Acylated and Unacylated Ghrelin. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065684