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Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K4EBP1 Signaling Pathway
Joint Authors
Chang, Xiaocen
Zhao, Yuyan
Ju, Shujing
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Orexin-A is a neuropeptide that orchestrates diverse central and peripheral processes.
It is now clear that orexin system plays a central role in the regulation of endocrine, paracrine, and neurocrine.
It is involved in the regulation of growth hormone, adrenocorticotropic hormone, thyroid, mineralocorticoid, and cortisol secretion.
These hormones may also serve as a kind of signal linking energy balance regulation, reproduction, stress response, and cardiovascular regulation.
Many studies have demonstrated the ability of orexin-A to regulate adrenocortical cells through the MAPK (mitogen-activated protein kinases) pathway.
The aim of our study is to investigate the effect of orexin-A on cortisol secretion via the protein 70 ribosomal protein S6 kinase-1 (p70S6K) and eukaryotic translation initiation factor 4E binding proteins (4EBP1) signaling pathway in adrenocortical cells.
We reported the first evidence that orexin-A stimulated p70S6K and 4EBP1 in human H295R adrenocortical cells in a concentration and time-dependent manner.
10−6 M orexin-A treatment for 1 hour was the most potent.
Our results also indicated that p70S6K and 4EBP1 kinases participated in controlling cortisol secretion via OX1 receptor in H295R cells, which implied important role of p70S6K and 4EBP1 kinases in regulating adrenal function induced by orexin-A.
American Psychological Association (APA)
Chang, Xiaocen& Zhao, Yuyan& Ju, Shujing. 2015. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K4EBP1 Signaling Pathway. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065690
Modern Language Association (MLA)
Chang, Xiaocen…[et al.]. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K4EBP1 Signaling Pathway. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065690
American Medical Association (AMA)
Chang, Xiaocen& Zhao, Yuyan& Ju, Shujing. Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K4EBP1 Signaling Pathway. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065690