Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients
Joint Authors
Akimoto, Tetsu
Nagata, Daisuke
Shiizaki, Kazuhiro
Otani-Takei, Naoko
Masuda, Takahiro
Honma, Sumiko
Watanabe, Yuko
Miki, Takuya
Kusano, Eiji
Asano, Yasushi
Kuro-o, Makoto
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Klotho is a single-pass transmembrane protein predominantly expressed in the kidney.
The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form.
Soluble Klotho is also generated from alternative splicing of the Klotho gene.
In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patients.
However, the relationship between the level of serum soluble Klotho and overall survival in hemodialysis patients, who exhibit a state of Klotho deficiency, remains to be delineated.
Here we prospectively followed a cohort of 63 patients with a mean duration of chronic hemodialysis of 6.7±5.4 years for a median of 65 months.
Serum soluble Klotho was detectable in all patients (median 371 pg/mL, interquartile range 309–449).
Patients with serum soluble Klotho levels below the lower quartile (<309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates.
Furthermore, the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29–13.48).
We conclude that there may be a threshold for the serum soluble Klotho level associated with a higher risk of mortality.
American Psychological Association (APA)
Otani-Takei, Naoko& Masuda, Takahiro& Akimoto, Tetsu& Honma, Sumiko& Watanabe, Yuko& Shiizaki, Kazuhiro…[et al.]. 2015. Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065692
Modern Language Association (MLA)
Otani-Takei, Naoko…[et al.]. Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065692
American Medical Association (AMA)
Otani-Takei, Naoko& Masuda, Takahiro& Akimoto, Tetsu& Honma, Sumiko& Watanabe, Yuko& Shiizaki, Kazuhiro…[et al.]. Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065692