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Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice
Joint Authors
Watada, Hirotaka
Fujitani, Yoshio
Mita, Tomoya
Nakajima, Kenichi
Osonoi, Yusuke
Takasu, Toshiyuki
Azuma, Kosuke
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Epidemiological data suggest that postprandial hyperglycaemia and hypoglycaemia are potential risk factors for cardiovascular disease.
However, the effects of repetitive postprandial glucose spikes, repetitive hypoglycaemia, and their combination on the progression of atherosclerosis remain largely unknown.
The present study investigated the effects of rapid rises and falls in glucose, and their combination, on the progression of atherosclerosis in apolipoprotein (apo) E-deficient mice.
In this study, apo E-deficient mice with forced oral administration of glucose twice daily for 15 weeks were used as a model of repetitive postprandial glucose spikes, and apo E-deficient mice given an intraperitoneal injection of insulin once a week for 15 weeks were used as a model of repetitive hypoglycaemia.
In addition, we established a model of both repetitive postprandial glucose spikes and hypoglycaemia by combining the above interventions.
Atherosclerosis was evaluated in all mice by oil red O staining.
Administration of ipragliflozin, a selective inhibitor of sodium-glucose cotransporter 2, in the mouse model of repetitive glucose spikes inhibited the progression of atherosclerosis, whereas long-term repetitive glucose spikes, repetitive hypoglycaemia, and their combination had no significant impact on atherosclerosis.
However, repetitive hypoglycaemia was associated with poor survival rate.
The results showed that repetitive hypoglycaemia reduces the survival rate without associated progression of atherosclerosis in apo E-deficient mice.
American Psychological Association (APA)
Nakajima, Kenichi& Mita, Tomoya& Osonoi, Yusuke& Azuma, Kosuke& Takasu, Toshiyuki& Fujitani, Yoshio…[et al.]. 2015. Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065693
Modern Language Association (MLA)
Nakajima, Kenichi…[et al.]. Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065693
American Medical Association (AMA)
Nakajima, Kenichi& Mita, Tomoya& Osonoi, Yusuke& Azuma, Kosuke& Takasu, Toshiyuki& Fujitani, Yoshio…[et al.]. Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065693