Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin
Joint Authors
Farngren, Johan
Schweizer, Anja
Foley, James E.
Pacini, Giovanni
Tura, Andrea
Ahrén, Bo
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy.
This analysis utilized data from a double-blind, randomized, placebo-controlled crossover study in 29 patients with type 2 diabetes treated with vildagliptin or placebo on top of stable insulin dose.
During two 4-week treatment periods, self-monitoring of plasma glucose was undertaken at 4 occasions every day.
Glucose values were used to assess several indices of glycemic control quality, such as glucose mean, GRADE, M-VALUE, hypoglycemia and hyperglycemia index, and indices of glycemic variability, such as standard deviation, CONGA, J-INDEX, and MAGE.
We found that vildagliptin improved the glycemic condition compared to placebo: mean glycemic levels, and both GRADE and M-VALUE, were reduced by vildagliptin ( P < 0.01 ) .
Indices also showed that vildagliptin reduced glycemia without increasing the risk for hypoglycemia.
Almost all indices of glycemic variability showed an improvement of the glycemic condition with vildagliptin ( P < 0.02 ) , though more marked differences were shown by the more complex indices.
In conclusion, the study shows that four-sample preprandial glucose self-monitoring is sufficient to yield information on the vildagliptin effects on glycemic control and variability.
American Psychological Association (APA)
Tura, Andrea& Farngren, Johan& Schweizer, Anja& Foley, James E.& Pacini, Giovanni& Ahrén, Bo. 2015. Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065710
Modern Language Association (MLA)
Tura, Andrea…[et al.]. Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065710
American Medical Association (AMA)
Tura, Andrea& Farngren, Johan& Schweizer, Anja& Foley, James E.& Pacini, Giovanni& Ahrén, Bo. Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type 2 Diabetes Treated with Insulin and Vildagliptin. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065710