Effects of Alendronate Sodium Content on the Interface Strengths of Composite Acrylic Bone Cement

Abstract EN

Objective.

Aim to study how the content of alendronate affected shear strengths at bone-bone cement-metal interfaces.

Methods.

All samples were divided into 6 groups, G0–G5.

On the 1st and 60th day after surgery, bone-bone cement interface shear strengths and bone densities were examined.

Interface strengths of metal-bone cement specimens were studied before immersion and 4 weeks after immersion.

Results.

On the 60th day, bone-bone cement interface shear strengths and bone densities showed significant differences (P<0.05), and compared with G0, G2–G5 values increased significantly (P<0.05), and the peak value was met in G3.

Compared with the 1st day, on the 60th postoperative day both factors decreased significantly in G0 and G1 (P<0.05).

Four weeks after immersion, with the increasing dose of alendronate, the shear strengths decreased gradually and in G5 decreased significantly (P<0.05).

Compared with before immersion, the metal-bone cement interface strengths decreased significantly 4 weeks after immersion (P<0.05).

Conclusions.

50–500 mg alendronate in 50 g cement powders could prevent the decrease of shear strengths at bone-bone cement interfaces and had no effect on metal-bone cement interface strengths.

While the addition dose was 100 mg, bone cement showed the best strengths.